The Seippel Gallery was founded by the art historian Dr Ralf-P. Seippel in Cologne in 1993. Since then, the focus has been on innovative and international contemporary art. In 2000, Galerie Seippel moved from the Belgian Quarter of Cologne to the more spacious premises at Zeughausstraße 26 (Haus der Stiftungen). It is now located in Cologne's main gallery quarter, within walking distance of the cathedral and directly opposite the famous "Römerturm", the oldest upright building in Cologne (50 p.c.).

Since 1997 Dr Ralf-P. Seippel has also been active in South Africa in the field of art consultancy and as a curator and organiser of commercial and non-commercial exhibitions. In 2007, the Seippel Gallery Johannesburg was founded as an exhibition venue for emerging European and South African contemporary art. Initially housed in August House, Doornfontein, Seippel Gallery Johannesburg later moved to a new exhibition space in Arts on Main, Downtown Johannesburg. Seippel Gallery Johannesburg currently exhibits at various venues.

The gallery's artists represent a broad field of contemporary art, including painting, sculpture, photography, graphics, video, installation and light installation.

In addition, numerous non-commercial exhibitions, workshops and artist-in-residence programmes have been supported by Galerie Seippel Cologne Johannesburg and organised together with other partners and renowned museums worldwide. 

Whenever possible, the gallery publishes catalogues of the exhibitions, either at the gallery or in collaboration with the gallery.

Galerie Seippel has been participating in international art fairs since 1996, amongst others: Art Cologne / Art Frankfurt / Cape Town Art Fair / Melbourne Art Fair / Photo Miami / Art Düsseldorf / Fiera Turin / Art Pampelonne / Art.Fair Cologne

Dr Ralf Seippel has worked internationally as a curator, consultant and/or editor for various cultural projects, amongst others: Collumina Light Art Project Cologne, 2018, 2020 and 2023 / PANTA RHEI. Everything flows. 150 years of RheinEnergie, 2022 / RESPONSIVE Light Art Project Halifax, 2017 and 2019 / Johannesburg Art Dialogues on Photography, 2011 / Mercedes Benz Prize for South African Art and Culture, 2000 - 2010 / Festival de la Luz Buenos Aires, 2011 / Architecture Biennale Sao Paulo, 2006 / South African Art and Culture Manifestation 2006 / New Identities, Museum Bochum, 2004 / Prague Biennale 1999 / ...